TLR3 and neoplasm: Twenty-four (24) hours after treatment of the KPC tumours, in active neutrophils, the combined treatments increased the transcription of genes (Figure A6E) associated with the NF-kβ transcription factor activity, TLR3 signalling, IFN-β production, myeloid leukocytes activation, and chemotaxis compared to the sham-exposed controls (Figure 8A1), whereas downregulated active neutrophil genes (Figure A6E) were associated with the TAP1 complex binding, antigen processing and presentation, and the regulation of T cell-mediated immunity (Figure 8A2).