CYBB and neoplasm: All neutrophil subsets showed an N2-like (pro-tumour growth, immune suppressive) gene expression pattern by overexpressing ENTPD1 [37], CXCR2 [33], S100A9 [38], IL10R [39,40], CD177 [41,42], OSM [43], TGFβR [44] (all but the active neutrophils subset cluster), PDL1, and MMP9 [45], and by downregulating pro-inflammatory genes like NOX2 [46], IFN-γ, and IFN-γR that are commonly associated with an N1-like phenotype.