L1CAM and melanoma: Despite this major role in the development of the neural system, further studied revealed that L1CAM is involved in many other tissues, such as in kidney morphogenesis [6], that it is present in granulocytes and lymphocytes [7], and in the development of several tumors, such as melanoma [5,8], renal cell cancer [9,10], colorectal cancer [11], gallbladder cancer [12], pancreatic cancer [13], and even gastrointestinal stromal tumors [14].