L1CAM was discovered over 40 years ago as a neural cell adhesion molecule; however, it has only recently gained attention in gynecological pathology for two reasons: as a surrogate marker of TRAF7 mutations in the diagnosis of adenomatoid tumors and well-differentiated papillary mesothelial tumors, and as a prognostic factor in endometrial carcinoma. Here, L1CAM is linked to endometrial carcinoma.