In addition, in an in vivo study, Chen et al. demonstrated that inactivating the TCF7L2 gene in mature adipocytes by removing the HMG-box DNA-binding domain resulted in glucose intolerance throughout the body and hepatic insulin resistance, accompanied by an increase in subcutaneous adipose tissue, adipocyte hypertrophy, and inflammation [32]. Here, TCF7L2 is linked to Insulin resistance.