Similarly, PLR (r = 0.290, p < 0.001), ESR (r = 0.257, p = 0.001), and NLR (r = 0.216, p = 0.008) all showed weak yet significant associations with AHI, indicating that, while these markers may contribute to the inflammatory profile of OSA, their predictive value may be lower than that of SIRI and monocyte counts. This evidence concerns the gene ESR1 and obstructive sleep apnea syndrome.