The factors that significantly decreased OS were BRCA1 gene mutation (10.09, p = 0.003), patients who underwent NAC (3.62, p = 0.013), no adjuvant HRT (0.28, p = 0.015), recurrence at follow-up (18.58, p < 0.001; local, 19.73, p < 0.001; distant, 40.42, p < 0.001), larger tumor size (1.23, p = 0.017), non-positive ER (0.33, p = 0.038), and non-positive PR (0.13, p = 0.002). Here, ESR1 is linked to neoplasm.