CXCL8 and hematopoietic and lymphoid cell neoplasm: Recent studies have shown that the activation of the JAK-STAT signalling pathway in chronic MPNs promotes the production of proinflammatory cytokines, leading to increased serum levels of IL-1, IL-6, IL-8, tumour necrosis factor alpha, and platelet-derived growth factor in patients with this type of haematological neoplasm, thereby inducing a significant proinflammatory state [14].