By means of a WES-based bioinformatics assay in the available family members, a heterozygous truncating ETS1 mutation, i.e., NM_005238.4:c.447T>G;p.(Tyr149*), was discovered and verified via a Sanger sequencing assay to co-segregate with DCM in the entire family. Here, ETS1 is linked to familial dilated cardiomyopathy.