ETS1 and congenital heart malformation: By means of a genome-wide single-nucleotide polymorphism array and whole-exome sequencing assays in 538 trios with congenital heart defects, Glessner et al. [113] identified a de novo ETS1 frameshift variant (c.1044_1049delCAAGGAinsTT or p.Lys349SerfsX2) in one patient with congenital heart malformations (hypoplastic left heart syndrome).