Pathogenic variants were detected in the ABCB4 gene in a patient with idiopathic cholestasis, in the APOB and CP genes in a patient with hepatic steatosis, in the ABCB4 gene in a patient with elevated liver enzymes, and in the MTTP and AGL genes in a patient with cryptogenic cirrhosis. The gene discussed is MTTP; the disease is cirrhosis, familial.