In comparison with transient elastography (FibroScan), serum biomarkers, including hyaluronan (HA), procollagen type III N-terminal peptide (PIIINP), type IV collagen (IVC), laminin (LN), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), demonstrate potential for detecting clinically significant liver fibrosis. This evidence concerns the gene GPT and Hepatic fibrosis.