In the same line as APOE, recent genome-wide association studies (GWASs) reported over 30 genetic loci (CLU, PICALM, CR1, BIN1, EPHA1, MS4A, ABCA7, CD33, and CD2AP) associated with a late-onset AD risk, highlighting the polygenic nature of the disease [33]. The gene discussed is PICALM; the disease is Alzheimer disease.