In a D-galactose and aluminum chloride-induced AD model, the ethyl acetate fraction of Physalis alkekengi fruit extract—rich in CA, nobiletin, and physalin B—has shown superior efficacy in reducing Aβ and tau burdens while modulating neuroinflammatory markers and suppressing p38 MAPK signaling. The gene discussed is MAPT; the disease is Alzheimer disease.