Angiotensin II, together with the receptor for angiotensin AT1 and the converting enzyme are expressed in arteries with atherosclerosis; angiotensin II is produced by angiotensin-converting enzyme in the atherosclerotic plaque and, in turn, they produce interleukin 6; thus, the renin—angiotensin system contributes to the inflammatory process in the arterial wall and to the development of acute coronary syndromes [107]. The gene discussed is ACE; the disease is atherosclerosis.