Nonetheless, Piezo2 (and Piezo1 to a lesser degree) provides a molecular interpretation for the HR dependence via pressure pulse detection and age dependence through a quad-phasic non-contact injury mechanism arising first as a transient acquired Piezo2 channelopathy, but later chronification follows with a repeated bout of non-contact injuries, leading to the degradation of this fine-tuning protein [4]. This evidence concerns the gene PIEZO2 and channelopathy.