Notably, genes encoding enzymes involved in the metabolism of vitamin D (CYP2R1, CYP27B1, and CYP24A1) harbor SNVs that have been associated with alterations in circulating vitamin D levels, immune cell function, and susceptibility to autoimmune diseases such as rs10741657 [11:14893332 (GRCh38)] CYP2R1, rs10877012 [12:57768302 (GRCh38)] CYP27B1, rs4809959 [20:54169320 (GRCh38)] CYP24A1, and rs731236 C>T [12:47844974 (GRCh38)] TaqI VDR [3,9,10]. This evidence concerns the gene CYP27B1 and autoimmune disease.