Recent studies, including those by Mo et al. and Schieving et al., have identified and thoroughly described cases of de novo HSP-SPAST leading to early-onset spastic paraplegia, accompanied by other motor disorders, progressive cognitive decline, motor disorders, and bulbar dysfunction—features typically absent in familial cases with the same SPAST variants [6,7,8,9]. This evidence concerns the gene SPAST and Spastic paraplegia.