Previous studies have identified noncoding variants and epigenetic marks in genes such as RBP4, FAM129B, SKI, and ABCA1 associated with cardiomyopathy risk [28], and ongoing research, including the TTR GWAS project (https://ttrgwas.com/), continues to explore the potential value of broad genomic profiling in families with atypical phenotypic patterns. This evidence concerns the gene RBP4 and cardiomyopathy.