RNF213 and Stroke: In a multicenter study of 112 Japanese patients with ICASO (excluding overt MMD), Ohara et al. [70] found that RNF213 carriers were significantly younger and had lower Framingham Cardiovascular Risk Score [71], Essen Stroke Risk Score [72], and Suita risk scores [73] (e.g., mean Framingham score: 10.7 vs. 15.3; p = 0.001).