The authors demonstrated that circ_0001591 promotes cell growth and invasion and reduces the apoptotic rate in melanoma cell lines by sponging miR-431-5p, causing the upregulation of the ROCK1/PI3K/AKT (Rho Associated Coiled-Coil Containing Protein Kinase 1/Phosphoinositide 3-kinase/Protein kinase B) signaling pathway [22]. Here, AKT1 is linked to melanoma.