Furthermore, variant Gly460Trp (rs4961) in ADD1, linked to arterial hypertension [8], and G367D (rs564185858) in ADDG, associated with cerebral palsy [34], represent compelling cases where mutations in an IDR (ADDA) or in a critical neck region (ADDG), and they have been implicated in disease despite not being predicted as destabilizing in our computational analysis. This evidence concerns the gene ADD1 and cerebral palsy.