Likewise, Posadas-Sánchez et al. reported an association between the rs428253 polymorphism in EBI3 and a reduced risk of premature coronary artery disease [47], and Guan et al. found that the rs4740 polymorphism was significantly linked to systemic lupus erythematosus in a Han Chinese cohort [39]. Here, EBI3 is linked to systemic lupus erythematosus.