MTHFR and myocardial infarction: With respect to A1298C, our results confirm the literature findings that the homozygous CC genotype was associated with increased risk of MI, especially when combined with smoking and high LDL levels [20] Our data align more closely with studies conducted in Eastern Europe and South Asia, which found a significant association between combined MTHFR C677T/A1298C genotypes and early-onset myocardial infarction, emphasizing a synergistic effect when both mutations are present [21].