Additionally, RNA-targeting CRISPR systems (e.g., Cas13) have been shown to reduce both sense and antisense C9orf72 repeat RNAs and their associated dipeptide repeat proteins, further supporting the therapeutic potential of CRISPR-based approaches for C9orf72-linked ALS [86,87,88,89]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.