Lower uromodulin and sodium levels in urine and elevated interleukin-6 and C-reactive protein (CRP) in serum were indicative of dehydration at baseline.Dehydration, body mass index (BMI), reduced uromodulin, and elevated serum interleukin-6, CRP, and lipopolysaccharide-binding protein were predictive of AKI on subsequent workdays. Here, IL6 is linked to acute kidney injury.