REN and endothelial dysfunction: These likely include systemic processes common to both conditions, such as increased systemic inflammation, platelet hyperreactivity, coagulation factor dysregulation, elevated metalloproteinases (MMPs), hypoxia, oxidative stress and activation of the renin–angiotensin system, endothelial dysfunction, myocardial remodeling [13,26,38,39,40,41,42,43,44,45,46].