Theoretically speaking, if it is assumed that GnRH antagonist-mediated suppression of elevated serum LH levels in PCOS patients during OS is likely to improve the impaired internal hormonal milieu and thereby optimize IVF outcomes, it stands to reason that it may be of benefit to administer antagonists from day 1 of stimulation itself. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.