While visceral fat is well recognized for its association with metabolic dysfunction—contributing to insulin resistance [11,12] and systemic inflammation marked by interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and macrophage chemoattractant protein-1 (MCP-1) [11,12]—growing evidence [13] suggests that local fat depots, such as perirenal fat and renal hilum fat, may play a more direct role in renal pathophysiology [13,14,15]. The gene discussed is IL6; the disease is Insulin resistance.