Other risk factors for diastolic dysfunction that literature reports with low to moderate strength of evidence include diabetes duration, BMI, hypertension, dyslipidemia, retinopathy, gender, glycemic control (HbA1c, but also glycemic variability), insulin therapy, atherogenic indices and some biomarkers, such as asprosin [10,44,45]. The gene discussed is INS; the disease is hypertensive disorder.