The minor criteria include the following: (1) body temperature exceeding 38 °C; (2) a known trigger such as malignancy, inflammatory or infectious disease, pregnancy, or recent vaccination; (3) a prompt clinical response to systemic corticosteroids or other appropriate treatments; and (4) abnormal laboratory findings such as leukocytosis (>8000/mm3), neutrophilia (>70%), elevated ESR (>20 mm/h), or a high value of CRP. The gene discussed is CRP; the disease is Increased total leukocyte count.