C4A and systemic lupus erythematosus: In a recent p a pooled analysis of five phase III trials, clinical remission or lupus low disease activity state (LLADAS) with normal serology are associated with a lower risk for severe or renal flares compared to those patients who presented serologically active remission (persistent anti-dsDNA positivity or low C3/C4 levels), possibly indicating deeper states of disease control in the former patients [162].