Anti-RNA binding protein (anti-RBP) autoantibodies, present in 50% of SLE patients, comprise distinct subtypes such as anti-Smith (anti-Sm), anti-ribonucleoprotein (anti-RNP), anti-Ro/SSA, and anti-La/SSB, each targeting specific RNA-protein complexes and linked to characteristic clinical features [58]. This evidence concerns the gene CALR and systemic lupus erythematosus.