Accordingly, the main predictors of SCD in TMEM43 mutation carriers include (1) male sex and (2) in females the presence of one or more of the following risk factors: LV systolic dysfunction (LVEF < 45%), NSVT, myocardial fibrosis on CMR, or >200 PVCs on 24 h Holter monitoring [8,10]. Here, TMEM43 is linked to Myocardial fibrosis.