Rosendahl et al. [58] tested caffeic acid in breast cancer cell lines (MCF-7, T47D, and MDA-MB-231), demonstrating that caffeic acid inhibits cell proliferation by modulating ER (estrogen receptor -a) and IGFIR (IGF type I receptor) levels, influencing cell cycle progression. The gene discussed is IGF1R; the disease is breast carcinoma.