NFKB1 and cancer: By lowering NF-κB levels no stimulus allows IκB (inhibitor of nuclear factor kappa B) to phosphorylate, ubiquitinate, and be degraded by the proteasome, thus releasing NF-κB so that it can translocate to the nucleus [83] and allow the transcription of adhesion molecules such as ICAM-1 (Figure 10), which plays a role in adhesion and metastasis of cancer cells [84].