FASLG and chronic kidney disease: In inflammatory conditions, the GLP-1RA PF1801 protects C2C12 myotubes from FAS ligand (FasL)-induced necroptosis by activating AMPK, promoting the degradation of PGAM5, increasing antioxidant gene expression, and reducing ROS accumulation [94]—mechanisms that are particularly relevant in the oxidative milieu of CKD.