We have demonstrated that the progressive accumulation of p-Tau containing NFTs seen in the human brain with DS-AD (Figure 2h, [62,63]) can be mimicked in DS mouse models by stereotaxic intracranial injection of neuron-derived extracellular vesicles (NDEVs) that contain p-Tau “seeds” from humans with DS-AD (Figure 2i and [61]). Here, MAPT is linked to Alzheimer disease.