Interestingly, DYRK1A (which is located on Hsa21 and over-expressed in the DS brain) is co-expressed with Notch and over-expression of DYRK1A (as in the DS brain) leads to inhibition of Notch signaling [107,109], altering the fate of neural progenitor cell proliferation as well as neuronal migration that could cause some of the developmental delays seen in children with DS [110]. The gene discussed is DYRK1A; the disease is Global developmental delay.