This region includes approximately 90 genes, fused to the centromeric part of mouse chromosome 17 from Pisd-ps2/Scaf8 to Pde10a, which includes 46 genes that are not homologous to Hsa21 and could therefore complicate the interpretation of results in this model, although it was the only mouse model for a long time that recapitulated DS human phenotypes [72], and was therefore used extensively for behavioral, pharmacological, and molecular DS studies [40,47,73]. This evidence concerns the gene SCAF8 and Dravet syndrome.