EGF and cancer: This glycosylation occurs within the epidermal growth factor (EGF)-like repeats of Notch-1’s extracellular domain (ECD), which contains serine and threonine residues that serve, as Notch signaling plays a central role in cancer biology, governing processes such as proliferation, apoptosis, angiogenesis, and evasion and tumor neovascularization [75].