TGFB1 and central nervous system cancer: Included in its protumoral activities is the transactivation of cyclooxygenases-2 (COX-2) in gliomas, inducing interleukin-10 (IL-10) expression in regulatory T-cells (Tregs) and macrophages, and increasing transforming growth factor beta 1 (TGF-β1), as selected examples of its protumoral activities [71,72,73].