CACNA1A and migraine disorder: In contrast to the variants of the CACNA1A gene reported in genetic databases, three novel variants of the CACNA1A gene were identified: ch19:13228374 G > C, ch19:13228428 G > C, and ch19:13228348 A > T. The first, ch19:13228374 G > C, was found in 6 patients (7%) with a family history of migraine and a young age of onset (6–20 years), presenting two different types of migraine: MA (n = 1) and MO (n = 5).