The pathogenesis of migraine involves impaired neuronal transmission, increased neuropeptide activity (e.g., calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP)), ion channel dysfunction, neuroinflammatory processes, and disturbances in serotonergic systems [10]. This evidence concerns the gene ADCYAP1 and migraine disorder.