Canagliflozin-treated HepG2 cells demonstrated increased expression of the cell growth regulator hepatocyte nuclear factor 4 (HNF4), with a reduced expression of cyclin D1, cyclin D2, and cdk4, resulting in cell cycle arrest in a hepatocellular carcinoma (HCC) cell line [180]. This evidence concerns the gene CCND2 and hepatocellular carcinoma.