In a representative example, ginseng-derived CDs significantly enhanced ferroptosis cell death in squamous carcinoma by increasing intracellular ROS, downregulating phospholipid glutathione peroxidase (GPX-4), and upregulating cyclooxygenase-2 (COX-2), effects often not achieved by conventional iron-based systems [81]. The gene discussed is PTGS2; the disease is squamous cell carcinoma.