CTFs of TDP-43 (25 kDa, 35 kDa) had greater aggregative potential than full-length TDP-43, which functioned as a nucleation site for the formation of amyloid-like fibrils; furthermore, CTFs and pTDP-43 were correlated with faster decline in ALSFRS-R and an earlier onset of respiratory failure. The gene discussed is TARDBP; the disease is respiratory failure.