Not only does FUS regulate the assembly and disassembly of stress granules, which are formed during cellular stress to protect untranslated mRNAs, it also decreases stress granule formation and aggregates in ALS patients where not only is mutant FUS aberrantly incorporated with stress granules that do not disassemble but also persistent aggregates resulting in toxic aggregates. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.