As we have reported that under vitiligo patient primary melanocytes and human normal keratinocytes co-culture conditions [25], the Rho-associated kinase ROCK inhibitor increased the expression of melanocyte survival and adherence pathways [38,39,40,41,42]—basic fibroblast growth factor (bFGF) [43,44,45,46,47,48,49] and E-cadherin [50,51,52], discoidin domain receptor tyrosine kinase 1 (DDR1) [52,53] and Glycoprotein NMB (GPNMB) [54]—which are essential for maintaining dendritic integrity, cell adherence and promoting proliferation via MAPK/p38, MITF-GPNMB expression [54,55,56,57,58]. The gene discussed is GPNMB; the disease is vitiligo.