Mechanistically (Figure 6), Y-27632 enhances the expression of E-cadherin and DDR1 (Figure 1), which stabilizes adherens junctions and preserves melanocyte residency within the basal epidermis; these adhesion molecules facilitate melanosome transfer and intercellular communication with keratinocytes—crucial processes disrupted in early vitiligo [51,52,53,59,60,61]. Here, CDH1 is linked to vitiligo.