According to the findings reported by Huang, X. et al., the long non-coding RNA Snhg12, whose expression is downregulated in obesity, plays a role in suppressing inflammatory responses in adipocytes, enhancing insulin sensitivity, and inducing macrophage polarization toward the anti-inflammatory M2 phenotype [90]. This evidence concerns the gene SNHG12 and obesity due to melanocortin 4 receptor deficiency.