Moreover, trends in the changes in fecal calprotectin levels during treatment in patients with HCC were comparable to those observed in the intestinal permeability biomarkers, i.e., serum zonulin and lipopolysaccharide binding protein (LBP), and opposite to those observed in Akkermansia to Enterobacteriaceae ratio and the gut microbiota alpha diversity. The gene discussed is LBP; the disease is hepatocellular carcinoma.