This notion found strong support in a recent study showing that Piezo1 functions as a cardiac mechanoreceptor at the origin of the intracellular Ca2+/Calmodulin-dependent kinase II (CaMKII)–histone deacetylase (HDAC) 4–myocyte enhancer factor 2 (MEF2) signaling cascade that initiates left ventricular hypertrophy along with fibrosis in response to cardiac pressure overload (Figure 4) [108]. Here, PIEZO1 is linked to left ventricular hypertrophy.