According to the latest European guidelines, the cutoff values for BNP and NT-pro-BNP in support of the diagnostic hypothesis of heart failure are 100 pg/mL for BNP and 300 pg/mL for NT-proBNP or >450 pg/mL if aged <55 years, >900 pg/mL if aged 55–75 years, and >1800 pg/mL if aged >75 years [2]. This evidence concerns the gene NPPB and heart failure.