THBS2 and hydrops fetalis: Lastly, several proteins involved in collagen turnover and extracellular matrix (ECM) regulation—such as endotrophin, thrombospondin-2 (THBS-2), ADAMTS-like protein 2 (ADAMTSL2), the large ECM protein SVEP1 (sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing 1), and vascular endothelial growth factor-C (VEGF-C)—have all been linked to cardiac remodeling and the pathophysiology of HF [49,96,101].