Abbreviations—ABC: ATP binding cassette; EGFR: epidermal growth factor receptor; ATP: adenosine triphosphate; DNA: deoxyribonucleic acid; RTK: receptor tyrosine kinases; CAF: cancer-associated fibroblast; TAM: tumor-associated macrophage; and HER 2: human epidermal growth factor receptor 2. The gene discussed is EGFR; the disease is cancer.