MAPK8 and Insulin resistance: Overexpression of the hepatic PXR target gene Lipin-1, along with cellular stress, promotes phosphorylation of c-Jun N-terminal kinase (JNK), whereas PXR-knockout (PXR-KO) mice exhibit suppressed JNK phosphorylation and show significant alleviation of high-fat diet (HFD)-induced insulin resistance [10] (Figure 2).