A study demonstrated that co-treatment with the traditional Chinese medicine formula Fengliang Changweikang (FLCWK) significantly reduced 5-FU-induced PXR activation, downregulated multidrug resistance gene 1 (MDR1) and P-glycoprotein (P-gp), and inhibited the IL-6/STAT3 signaling pathway, thus sensitizing cancer cells to 5-FU [114]. The gene discussed is NR1I2; the disease is cancer.