Notably, melanoma cells can express receptors for calprotectin, including RAGE (Receptor for Advanced Glycation End-Products), EMMPRIN (Extracellular Matrix Metalloproteinase Inducer, also known as Basigin or CD147), TLR4 (Toll-like receptor 4), and MCAM (Melanoma Cell Adhesion Molecule, CD146) [10,11,12,13]. The gene discussed is MCAM; the disease is melanoma.