TNFRSF12A and familial pancreatic carcinoma: In a pancreatic cancer cachexia model, Fn14 activation in muscle fibers led to the upregulation of the protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol-requiring protein (1α IRE1α) arms of the unfolded protein response, which correlated with suppressed protein synthesis [43].