Synergistic effects of Gal-9–TIM-3 and PD-1:PD-L1 axis blockade was also observed in a C1498 AML B6 mouse model wherein treatment of Lgals9-/- KO mice with anti-PD-L1 (MIH7) restored CD8+ T cell function and prolonged survival to a greater extent than Lgals9-/- KO mice without PD-L1 ab [235]. Here, PDCD1 is linked to acute myeloid leukemia.