Several additional blocking abs targeting multiple Gal-9 axis binding partners, including TIM-3, CEACAM1, or PD-1 are also being examined in multiple advanced cancer types, including melanoma, Merkel cell, brain, cervical, colon, esophageal, gastric, liver, lung, and pancreatic cancer, as well as leukemia and lymphoma (Table 1). The gene discussed is LGALS9; the disease is melanoma.