FLT4 and gastric cancer: In addition, elevated Gal-9 expression suppressed proliferation and triggered apoptosis of gastric cancer cells (Figure 5) by inducing caspase-cleaved keratin 18 (CCK18) and reducing vascular endothelial growth factor receptor-3 (VEGFR-3) and insulin-like growth factor-1 receptor (IGF-1R) expression [179].