Cd showed positive and significative correlations with NGAL, KIM-1, OPN, and Cys-C, indicating that the higher the concentration of Cd was, the higher the concentrations of the biomarkers of early kidney damage were; the same behavior was observed between Cu and NGAL, KIM-1, a1-MG, OPN, Cys-C, and CLU; a negative and significative correlation was observed with eGFR; Hg only showed correlation with CLU; and Zn presented significant negative correlations with NGAL only. The gene discussed is SPP1; the disease is Nephropathy.