TIMP1 and brain ischemia: Moreover, the cell survival rate of the TIMP-i group was lower than the model group, while that of the AT-50 group and AT-150 group significantly increased (Figure 7G), indicating TIMP-1 played a crucial role in the mechanism of combined AS and TMP treatment for OGD injury, and it is expected to become an important target for developing innovative drugs for treating cerebral ischemia in the future.